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Prehospital antiplatelet
therapy linked to COVID-19
patient survival

Association of prehospital antiplatelet therapy with survival in patients hospitalized with COVID-19: A propensity score-matched analysis


  • Question: Coronavirus disease 2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk. What is the impact of prehospital antiplatelet therapy on in-hospital mortality?
  • Findings: In-hospital mortality was significantly lower in patients receiving prehospital antiplatelet therapy, resulting in a 2.6% absolute reduction in mortality. On average, 39 patients needed to be treated to prevent one in-hospital death. In the antiplatelet therapy group, there was a significantly lower rate of pulmonary embolism and higher rate of epistaxis.
  • Meaning: In the largest observational study to date of prehospital antiplatelet therapy in patients with COVID-19, there was an association with significantly lower in-hospital mortality. Randomized controlled trials in diverse patient populations with high rates of baseline comorbidities are needed to determine the ultimate utility of antiplatelet therapy in COVID-19.