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    RWD Publications - Retrospective analysis of pregnant women with COVID-19 | Cerner

    Pregnant women are potentially a high-risk population during infectious disease outbreaks such as COVID-19, because of physiologic immune suppression in pregnancy. However, data on the morbidity and mortality of COVID-19 among pregnant women, compared to nonpregnant women, are sparse and inconclusive. We sought to assess the impact of pregnancy on COVID-19 associated morbidity and mortality, with particular attention to the impact of pre-existing comorbidity.

    https://www.cerner.com/rwd-publications/retrospective-analysis-of-pregnant-women-with-covid-19

    RWD Publications - Predicting interactions of drugs in COVID-19 clinical trials | Cerner

    Numerous drugs are currently under accelerated clinical investigation for the treatment of coronavirus disease 2019 (COVID‐19); however, well‐established safety and efficacy data for these drugs are limited. The goal of this study was to predict the potential of 25 small molecule drugs in clinical trials for COVID‐19 to cause clinically relevant drug‐drug interactions (DDIs), which could lead to potential adverse drug reactions (ADRs) with the use of concomitant medications.

    https://www.cerner.com/rwd-publications/predicting-interactions-of-drugs-in-covid-19-clinical-trials

    RWD Publications - Racial disparities in COVID-19 outcomes | Cerner

    Racial disparities in COVID-19 outcomes exist despite comparable Elixhauser comorbidity indices between Blacks, Hispanics, Native Americans, and Whites. Factors contributing to racial inequities in outcomes from coronavirus disease 2019 (COVID-19) remain poorly understood. We compared by race the risk of 4 COVID-19 health outcomes––maximum length of hospital stay (LOS), invasive ventilation, hospitalization exceeding 24 h, and death––stratified by Elixhauser comorbidity index (ECI) ranking. Outcomes and ECI scores were constructed from retrospective data obtained from the Cerner COVID-19 De-Identified Data cohort.

    https://www.cerner.com/rwd-publications/racial-disparities-in-covid-19-outcomes

    RWD Publications - Prognostic values of serum ferritin and D-dimer trajectory in COVID-19 patients | Cerner

    Cytokine storm syndrome in patients with COVID-19 is mediated by pro-inflammatory cytokines resulting in acute lung injury and multiorgan failure. Elevation in serum ferritin and D-dimer is observed in COVID-19 patients. To determine prognostic values of optimal serum cutoff with trajectory plots for both serum ferritin and D-dimer in COVID-19 patients with invasive ventilator dependence and in-hospital mortality.

    https://www.cerner.com/rwd-publications/prognostic-values-of-serum-ferritin-and-d-dimer-trajectory-in-covid-19-patients